Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (6): 2413-2414.doi: 10.4103/NRR.NRR-D-25-00178

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Three-dimensional patientderived cell models represent an emerging frontier in the study of neurodegenerative diseases

Rachel J. Boyd, Vasiliki Mahairaki*   

  1. Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA (Boyd RJ, Mahairaki V) Division of Geriatric Medicine and Gerontology, Johns Hopkins School of Medicine, Baltimore, MD, USA (Boyd RJ) The Richman Family Precision Medicine Center of Excellence in Alzheimer’s Disease, Johns Hopkins School of Medicine, Baltimore, MD, USA (Boyd RJ, Mahairaki V)
  • Online:2026-06-15 Published:2025-09-18
  • Contact: Vasiliki Mahairaki, PhD, vmachai1@jhmi.edu.
  • Supported by:
    The authors would like to acknowledge support by The Richman Family Precision Medicine Center of Excellence in Alzheimer’s Disease at Johns Hopkins. This work was supported by the Canadian Institutes of Health Research (DFD-181599) and the National Institutes of Health (T32AG058527) to RJB and R0190106435 to VM.

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Abstract: Neurodegenerative disorders represent an increasingly pertinent public health crisis. As a greater proportion of the population ages, neurodegenerative disorders and other diseases of aging place undue burdens on patients, caregivers, and healthcare workers. Alzheimer’s disease (AD) and Parkinson’s disease represent the two most common neurodegenerative disorders in the population, affecting over 65 million people, worldwide. These diseases and others often arise due to complex interactions between polygenic risk and environmental exposures, which is often reflected in variable clinical presentation and response to therapeutic interventions.