Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (7): 2625-2633.doi: 10.4103/NRR.NRR-D-25-00402

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MicroRNAs in the pathogenesis of neurodegenerative disorders: Potential as therapeutic targets

Aditi Singh1 , Manivannan Subramanian1 , Amit Singh1, 2, 3, 4, *   

  1. 1 Department of Biology, University of Dayton, Dayton, OH, USA;  2 Premedical Program, University of Dayton, Dayton, OH, USA;  3 Leonard A. Mann Endowed Chair in Natural Sciences, University of Dayton, Dayton, OH, USA;  4 Center for Genomic Advocacy (TCGA), Indiana State University, Terre Haute, IN, USA
  • Online:2026-07-15 Published:2025-10-17
  • Contact: Amit Singh, PhD, asingh1@udayton.edu.
  • Supported by:
    This work was supported by 1RO1EY032959-01 from NIH, Leonard A Mann Chair Endowment Fund, from the University of Dayton (to AS); Knights Templar Eye Foundation grant (to MS).

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Abstract: Neurodegenerative diseases (neurodegenerative disorders) are marked by the progressive degeneration of the structure and function of the central nervous system. They may result in the deterioration of cognitive, motor, and functional abilities. Diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis represent some of the most prominent examples of neurodegenerative disorders. Despite scientific advancement in understanding disease pathology and prognosis, the therapeutic strategies available for management remain limited. In recent years, microRNAs, small non-coding RNA molecules, have emerged as key players in the pathogenesis of neurodegenerative disorders. Therefore, understanding how these microRNAs affect disease pathology and pathway signaling is essential, and may open microRNAs as new avenues for potential therapeutic intervention. This review explores the role of microRNAs in various neurodegenerative diseases, discuss how microRNAs affect signaling pathways, and examine the potential of microRNAs as therapeutic targets.

Key words: Alzheimer’s disease, amyotrophic lateral sclerosis, Drosophila, gene expression regulation, genetics, Huntington’s disease, microRNA, neurodegenerative diseases, Parkinson’s disease