Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (7): 2826-2827.doi: 10.4103/NRR.NRR-D-25-00312

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Rethinking dementia in the oldest old: Lessons to learn for the diagnosis and treatment of Alzheimer’s disease

Chiara Giuseppina Bonomi, Caterina Motta, Martina Gaia Di Donna, Martina Poli, Giacomo Koch, Alessandro Martorana*   

  1. Memory Clinic and Neurodegenerative Dementia Research Unit, Policlinico Tor Vergata, University of Rome “Tor Vergata,” Rome, Italy (Bonomi CG, Motta C, Di Donna MG, Poli M, Martorana A) Department of Clinical and Behavioral Neurology, Santa Lucia Foundation IRCCS, Rome, Italy (Koch G) Department of Neuroscience and Rehabilitation, University of Ferrara, and Center for Translational Neurophysiology of Speech and Communication (CTNSC), Italian Institute of Technology (IIT), Ferrara, Italy (Koch G)
  • Online:2026-07-15 Published:2025-10-20
  • Contact: Alessandro Martorana, MD, PhD, martorana@med.uniroma2.it.

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Abstract: Dementia and Alzheimer’s disease (AD) are both age-related conditions that predominantly affect older adults. According to prevalence studies, the burden of these diseases on society is expected to increase in the coming years, particularly in relation to rising longevity and life expectancy. Advances in therapeutic and preventive strategies are needed to help reduce their global burden, which remains among the most significant health challenges in aging populations (Brookmeyer et al., 2007).