Abstract: G l u t a m a t e r e c e p t o r s a n d s c h i z o p h r e n i a : Schizophrenia is a chronic mental disorder affecting approximately 1% of the global population, with 70%–80% heritability. It has a multifactorial etiology involving both environmental factors and a complex polygenic genetic architecture. Over the last two decades, large-scale genome-wide approaches revealed contributions of common variants with individually small effect sizes and of rare copy number variants with a large effect size.