Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (7): 2964-2965.doi: 10.4103/NRR.NRR-D-25-00805

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Aging epigenome begins to change in age-related neurodegenerative diseases

Adam Zaretsky, Debra Toiber*   

  1. Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel 
    The Brain Sciences School, Ben-Gurion University of the Negev, Beer Sheva, Israel
  • Online:2026-07-15 Published:2026-03-27
  • Contact: Debra Toiber, PhD, toiber@bgu.ac.il.
  • Supported by:
    This work was funded by the David and Inez Myers Foundation, the Israeli Ministry of Science and Technology (MOST), and The Israel Science Foundation (No. 422/23) (to DT).

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Abstract: With the rapid increase in the aging population comes a rise in the incidence and prevalence of neurodegenerative diseases. Therefore, it is critical to understand the molecular changes that occur, which can either cause disease or make brains resilient. Epigenetic changes are a common suspect and target, not only because they are among the hallmarks of aging, but also because they are flexible and could potentially be reversed.