Abstract: Neuronal cells require precise and stable control of gene expression throughout their extended lifespan, which presents numerous challenges for gene transcription. While traditional studies of transcriptional regulation have primarily focused on canonical DNA-binding factors, there is an increasing recognition of the role of regulatory RNAs and RNA-binding proteins (RBPs) in modulating this process. A wide repertoire of RNAs is expressed in eukaryotic cells, including many forms of non-coding RNAs that are transcribed from most genomic regions (Djebali et al., 2012). The majority of these non-coding RNAs play crucial roles in genome regulation, functioning both as products and regulators of gene transcription.