Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (7): 1193-1194.doi: 10.4103/1673-5374.235030

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Lateral olfactory tract usher substance (LOTUS) protein, an endogenous Nogo receptor antagonist, converts a non-permissive to permissive brain environment for axonal regrowth

Tomoko Hirokawa, Kohtaro Takei   

  1. Molecular Medical Bioscience Laboratory, Yokohama City University Graduate School of Medical Life Science, Yokohama, Japan
  • Received:2018-05-03 Online:2018-07-15 Published:2018-07-15
  • Contact: Kohtaro Takei, Ph.D.,kohtaro@yokohama-cu.ac.jp.
  • Supported by:

    This work was supported by a grant-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by grants for Research and Development project of Yokohama City University.

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Abstract:

It is well known that primates, including humans, hardly recover motor function after spinal cord injury (SCI) when compared with non-primate mammals such as rodents. This limited functional recovery is in part due to a non-permissive environment of the central nervous system (CNS) inhibiting axonal regrowth. This inhibitory environment for axonal regrowth is mainly caused by interaction of axon growth inhibitors with their common receptor, Nogo receptor-1 (NgR1). Axon regrowth inhibitors such as Nogo proteins, myelin associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgp) and B lymphocyte stimulator (BLyS) are derived from glial cells in damaged brain.