Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (1): 43-45.doi: 10.4103/1673-5374.241043

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An innovative approach for the treatment of Alzheimer’s disease: the role of peroxisome proliferator-activated receptors and their ligands in development of alternative therapeutic interventions

Luca Piemontese   

  1. Dipartimento Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Bari, Italy
  • Online:2019-01-15 Published:2019-01-15
  • Contact: Luca Piemontese, PhD, luca.piemontese@uniba.it
  • Supported by:

    This work was supported by Intervento cofinanziato dal Fondo di Sviluppo e Coesione 2007-2013 –APQ Ricerca Regione Puglia “Programma regionale a sostegno della specializzazione intelligente e della sostenibilità sociale ed ambientale - FutureInResearch”. Project ID: I2PCTF6.

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Abstract:

Alzheimer’s disease is a multifactorial pathology, for which no cure is currently available. Nowadays, researchers are moving towards a new hypothesis of the onset of the illness, linking it to a metabolic impairment. This innovative approach will lead to the identification of new targets for the preparation of new effective drugs. Peroxisome proliferator-activated receptors and their ligands are the ideal candidates to reach the necessary breakthrough to defeat this complicate disease.

Key words: Alzheimer’s disease, multifunctional drugs, peroxisome proliferator-activated receptors, type 3 diabetes, innovative therapies, type 2 diabetes mellitus, metabolism, neuroinflammation