Abstract:

Peripheral neuropathy constitutes a highly incidental condition and a major public health concern worldwide. This pathology is triggered by peripheral nervous system damage as a consequence of systemic disease or ischemic-traumatic lesion. In the latter case, nerve crush, partial or total transection and stretch injury interrupt nerve conduction and impair sensitivity and motility of the innervated area, which brings about partial or total functional loss in the affected limb and disabling neuropathic pain. For these reasons, digging into the molecular mechanisms underlying peripheral neuropathy becomes essential for the development of successful therapeutic strategies.