Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (8): 1470-1472.doi: 10.4103/1673-5374.253533

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Improvement of ataxia in a patient with cerebellar infarction by recovery of injured cortico-ponto-cerebellar tract and dentato-rubro-thalamic tract: a diffusion tensor tractography study

Sung Ho Jang 1, Hyeok Gyu Kwon 2   

  1. 1Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea
    2Department of Physical Therapy, College of Health Science, Eulji University, Gyeonggi, Republic of Korea
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Hyeok Gyu Kwon, PhD, khg0715@hanmail.net.
  • Supported by:
    This study was supported by Bumsuk Academic Research Fund in 2017 (to HGK). The funding body played no role in the study conception design, in the collection, analysis and inter pretation of data, in the preparation and writing of the report, and in the decision to submit the article for publication.
     

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Abstract:

Coordinated movement is generated by communication between the cerebrum and cerebellum via the cerebellar peduncles (CPs). The CPs are classified into three types (superior, middle, and inferior), and each includes a variety of neural tracts. Among those tracts, the cortico-ponto-cerebellar tract (CPCT), a middle CP, is involved in motor planning and initiation of movement, while the dentato-rubro-thalamic tract (DRTT), a superior CP, is involved in motor coordination, movement timing, verbal fluency, and working memory . Injuries of these two neural tracts in various brain pathologies are commonly accompanied by ataxia. In particular, cerebellar infarction results in inevitable injuries of the CPCT and the DRTT, and over 50% of patients with cerebellar infarction experience ataxia.