Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (10): 1719-1720.doi: 10.4103/1673-5374.257517

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Fine-tuning the response of growth cones to guidance cues: a perspective on the role of microRNAs

Sarah E. Walker, Gaynor E. Spencer, Robert L. Carlone   

  1. Department of Biological Sciences, Brock University, Ontario, Canada
  • Online:2019-10-15 Published:2019-10-15
  • Contact: Robert L. Carlone, PhD, rcarlone@brocku.ca.
  • Supported by:

    This work was supported by grants from the Natural Sciences and Engineering Research Council of Canada (2015-03780, to GES; and 2017-00008, to RLC)

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Abstract:

In the development and regeneration of the nervous system, neurons face the complex task of establishing and/or repairing neuronal connections and contacts. The formation of these neuronal circuits is largely coordinated by tightly regulated temporal and spatial changes in mRNA translation, which enables incredibly precise control over protein expression and localization. Local mRNA translation in specific cellular compartments appears to play a role in many processes that are important to nervous system development and regeneration, including: cell survival, migration, growth cone guidance, and synaptogenesis.