Neural Regeneration Research ›› 2019, Vol. 14 ›› Issue (12): 2091-2092.doi: 10.4103/1673-5374.262582

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Cross-talk between T-cells and gut-microbiota in neurodegenerative disorders

Rodrigo Pacheco   

  1. Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa, Santiago, Chile
  • Online:2019-12-15 Published:2019-12-15
  • Contact: Rodrigo Pacheco, PhD, rpacheco@cienciavida.org or rodrigo.pacheco@unab.cl.
  • Supported by:

    This work was supported by Programa de Apoyo a Centros con Financiamiento Basal AFB-170004 (to Fundación Ciencia & Vida) from “Comisión Nacional de Investigación Científica y Tecnológica de Chile (CONICYT)” and by grants FONDECYT-1170093 from Fondo Nacional de Desarrollo Científico y Tecnológico de Chile, MJFF-10332.01 and MJFF15076 from Michael J. Fox Foundation for Parkinson Research.

Abstract:

The emerging role of gut microbiota as a key player in the development of neurodegenerative disorders: Mammals have evolved together with commensal microbiota to establish a symbiotic relationship in which they regulate reciprocally by synthesizing and responding to several common chemical substances. In this regard, gut microbiota constitutes a consortium of bacteria that not only participates in the degradation of nutrients, but also produces metabolites, fatty acids and neurotransmitters that can act on the enzymes and receptors expressed in eukaryotic cells, which considerably affects the physiology of the host and contribute to maintaining homeostasis.