Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (10): 736-740.

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X-box-binding protein 1-modified neural stem cells for treatment of Parkinson’s disease

Lihui Si1, Tianmin Xu1, Fengzhang Wang2, Qun Liu2, Manhua Cui1   

  1. 1  Department of Gynecology and Obstetrics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
    2  Department of Neurology, Norman Bethune First Hospital of Jilin University, Changchun 130021, Jilin Province, China
  • Received:2012-01-06 Revised:2012-03-15 Online:2012-04-05 Published:2012-04-05
  • Contact: Manhua Cui, M.D., Professor, Doctoral supervisor, Chief physician, Department of Gynecology and Obstetrics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China cuimanhua@126.com
  • About author:Lihui Si☆, M.D., Chief physician, Department of Gynecology and Obstetrics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China

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Abstract:

X-box-binding protein 1-transfected neural stem cells were transplanted into the right lateral ventricles of rats with rotenone-induced Parkinson’s disease. The survival capacities and differentiation rates of cells expressing the dopaminergic marker tyrosine hydroxylase were higher in X-box-binding protein 1-transfected neural stem cells compared to non-transfected cells. Moreover, dopamine and 3,4-dihydroxyphenylacetic acid levels in the substantia nigra were significantly increased, α-synuclein expression was decreased, and neurological behaviors were significantly ameliorated in rats following transplantation of X-box-binding protein 1-transfected neural stem cells. These results indicate that transplantation of X-box-binding protein 1-transfected neural stem cells can promote stem cell survival and differentiation into dopaminergic neurons, increase dopamine and 3,4-dihydroxyphenylacetic acid levels, reduce α-synuclein aggregation in the substantia nigra, and improve the symptoms of Parkinson’s disease in rats.

Key words: X-box-binding protein 1, neural stem cells, Parkinson’s disease, α-synuclein, dopamine