Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, eventually manifesting in severe cognitive dysfunction. Despite the recent proliferation of encouraging preclinical studies and clinical trials, scientific society is still far from a complete consensus regarding the AD etiology and pathogenesis. Accordingly, no approved AD‐modifying therapies are currently available. Nevertheless, novel concepts predicated upon the latest discoveries and comprehension of the disease as a multifactorial disorder are paving the road to the successful AD treatment.