Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (5): 924-925.doi: 10.4103/1673-5374.297092

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Recovery of gait and injured corticoreticulospinal tracts in a patient with diffuse axonal injury

Sung Ho Jang, You Sung Seo*   

  1. Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea
  • Online:2021-05-15 Published:2020-12-29
  • Contact: You Sung Seo, MS, yousung1008@hanmail.net.

Abstract: Diffuse axonal injury (DAI) is defined as the presence of microscopic axonal damage in the white matter of the brain produced by mechanical forces and is characterized histologically by widespread damage to axons (Maxwell et al., 1997). Diffusion tensor imaging (DTI) allows evaluation of the integrity of the white matter of brain to be determined by virtue of its ability to image water diffusion characteristics (Basser et al., 1994). Therefore, DTI has a unique advantage to detect DAI and many studies using DTI have investigated DAI (Wang et al., 2008). Furthermore, previous studies using DTI have demonstrated the recovery of DAI in the corticospinal tract, cingulum, and white matter (Kim et al., 2009; Edlow et al., 2016; Jang and Seo, 2016). There is no study on the recovery of DAI in the corticoreticulospinal tract (CRT) which is involved in gait function by innervating axial and leg muscles (Matsuyama et al., 2004).