Neural Regeneration Research ›› 2021, Vol. 16 ›› Issue (6): 1218-1220.doi: 10.4103/1673-5374.300433

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Schwann-like adipose-derived stem cells as a promising therapeutic tool for peripheral nerve regeneration: effects of cholinergic stimulation

Roberta Piovesana, Alessandro Faroni, Ada Maria Tata, Adam J. Reid*   

  1. Department of Biology and Biotechnologies “Charles Darwin”, Sapienza, University of Rome, Rome, Italy (Piovesana R, Tata AM)
    Blond McIndoe Laboratories, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK (Piovesana R, Faroni A, Reid AJ)
    Research Centre of Neurobiology “Daniel Bovet”, Sapienza, University of Rome, Rome, Italy (Tata AM)
    Department of Plastic Surgery & Burns, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK (Reid AJ) 
  • Online:2021-06-15 Published:2020-12-31
  • Contact: Adam J. Reid, MBChB, FRCS (Plast), PhD, Adam.Reid@manchester.ac.uk.
  • Supported by:
    The present work was supported by Ateneo Sapienza Funds 2017 (RM11715C7F959CA4) to AMT and “Avvio Giovani” Project 2018 (AR11816435A0F81D) from Ateneo Sapienza to RP. RP fellowship was also supported by CIB 2018. AF and AJR are supported by the Hargreaves and Ball Trust, the Academy of Medical Sciences (AMS-SGCL7), and by Seed Corn Funding from the Rosetrees Trust and the Stoneygate Trust (M746). 

    The authors are very grateful to Paul Mellidi for the illustration in Figure 1B.

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Abstract: Peripheral nerve injuries (PNIs) are a common clinical problem usually as a consequence of trauma. Despite optimal surgical management, PNI has a lifelong impact on function and wellbeing of the patient.