Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (8): 565-571.

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8-hydroxy-dipropylaminotetralin promotes neural plasticity in epileptic rats with depression

Ping Yang1, Meizhen Sun2, Liang Li3, Yihua Shen1   

  1. 1 Department of Psychosomatic Diseases, Second People’s Hospital of Hunan Province, Changsha 410007, Hunan Province, China
    2 Department of Neurology, First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
    3 Department of Anatomy, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China
  • Received:2011-11-24 Revised:2012-02-04 Online:2012-03-15 Published:2012-03-15
  • Contact: Meizhen Sun, M.D., Professor, Department of Neurology, First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China meizhensun23@yahoo.com
  • About author:Ping Yang★, Master, Department of Psychosomatic Diseases, Second People’s Hospital of Hunan Province, Changsha 410007, Hunan Province, China

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Abstract:

Rats with chronic pilocarpine-induced temporal lobe epilepsy complicated with depression were studied. Anti-5-bromodeoxyuridine immunofluorescence staining and Timms staining showed that neurogenesis within the hippocampal dentate gyrus and mossy fiber sprouting were increased in model rats. Neurogenesis within the hippocampal dentate gyrus was further enhanced, while mossy fiber sprouting was decreased in model rats administered carbamazepine alone or in combination with the 5-hydroxytryptamine 1A receptor agonist, 8-hydroxy-dipropylaminotetralin (0.1 and 1 mg/kg). Among the groups, the effect was the most significant in rats receiving carbamazepine in conjunction with 1 mg/kg 8-hydroxy-dipropylaminotetralin. Thus, high dose 8-hydroxy-dipropylaminotetralin can improve neural plasticity in epileptic rats with depression.

Key words: epilepsy, depression, 5-hydroxytryptamine 1A receptors, 8-hydroxy-dipropylaminotetralin, neural plasticity