Abstract: Axonal regeneration after injuries to the nervous system has been extensively studied due to its implication in motor and sensory functional recovery. Distinct types of regeneration has been identified, such as canonical axonal regeneration, defined as the growth of axons from the transected axonal stump to reinnervate the original target, or regenerative sprouting, in which the growth occurs from a region of the damaged axon either close or far from the injury site (Tuszynski and Steward, 2012). Both types of axonal regeneration depend on cellular and molecular responses of the injured neuron. However, undamaged neurons can also react to an injury-induced environment by extending sprouts along their axons that functionally synapse with denervated targets, a process known as collateral sprouting (Collyer et al., 2014; Bao et al., 2016).