Abstract: Introduction: Recently, sphingolipids (SphLs) have become increasingly appreciated as a family of molecules involved in the growth, differentiation, and death of the central nervous system  cells. The disequilibrium among the different SphLs leads to changes in the neuronal cell physiology and induces the development of neurodegenerative diseases (Alessenko and Albi, 2020). Sphingomyelin (SM), sphinganin (Sphn), sphingosine (Sph), sphingosine-1-phosphate (S1P) and ceramide (Cer) are the most well-studied group of SphLs responsible for neurodegeneration, as well as derived molecules such as glucosylceramide or cerebroside (GCer) and galactosylceramide (GalCer) and finally more complex molecules such as as gangliosides.