Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (3): 643-648.doi: 10.4103/1673-5374.320994

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Limitations in activities of daily living increase the risk of stroke in older Chinese adults: a population-based longitudinal study

Zhuang-Sheng Wei1, #, Yu-Sen Chen1, #, Ying Wu1, Chen-Yao Kang1, Jia-Yuan Wu1, Yu Yang2, Hao Wu1, Bin Zhao1, Zhou Liu1, *   

  1. 1Department of Neurology, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China; 2Department of Geriatrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
  • Online:2022-03-15 Published:2021-10-15
  • Contact: Zhou Liu, MD, liuzhou@gdmu.edu.cn.
  • Supported by:
    This study was supported by a grant from the Clinical Research Project of Affiliated Hospital of Guangdong Medical University of China, Nos. LCYJ2018A00 (to ZL) and LCYJ2019C006 (to YSC); the Natural Science Foundation of Guangdong Province of China, No. 2020A151501284 (to ZL); the Science and Technology Planning Project of Zhanjiang of China, No. 2018A01021 (to ZL); and a grant from the Characteristic Innovation Projects of Colleges and Universities in Guangdong Province of China, No. 2019KTSCX045 (to ZL).

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Abstract: It remains unclear whether limitations in activities of daily living (ADL) increase the risk of stroke in older Chinese adults. This longitudinal study used data from the Chinese Longitudinal Healthy Longevity Survey to investigate the effects of limitations in ADL on the incidence of stroke in older adults. Between 2002 and 2011, 46,728 participants from 22 provinces in China were included in this study. Of participants, 11,241 developed limitations in ADL at baseline. A 3-year follow-up was performed to determine the incidence of stroke. During the 3-year follow-up, 929 participants (8.26%) and 2434 participants (6.86%) experienced stroke in the ADL limitations group and non-ADL limitations group, respectively. Logistic regression was used to analyze the effect of ADL limitations on the risk of stroke. The results showed that after adjusting for the confounding factors gender, age, weight, hypertension, diabetes, heart disease, natural teeth, hearing impairment, visual impairment, smoking, alcohol abuse, exercise, ethnicity, literacy, residential area, and poverty, the ADL limitations group had a 77% higher risk of developing stroke than the non-ADL limitations group. After propensity score matching, the ADL limitations group still had a 33% higher risk of developing stroke than the non-ADL limitations group (OR = 1.326, 95% CI: 1.174–1.497). These findings suggest that limitations in ADL are a stroke risk factor.

Key words: activities of daily living, Chinese Longitudinal Healthy Longevity Survey, cohort, older Chinese individuals, propensity score matching, risk, stroke, survey

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