Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (6): 457-462.

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Electroacupuncture effects on cortical neurons, as well as Janus kinase 2-signal transducer and activator of transcription 3 signal transduction pathway, in a rat model of cerebral ischemia

Rong Liu, Nenggui Xu, Wei Yi, Kangbai Huang   

  1. Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Received:2011-10-27 Revised:2012-01-30 Online:2012-02-25 Published:2012-02-25
  • Contact: Nenggui Xu, Ph.D., Researcher, Doctoral supervisor, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; Wei Yi, Ph.D., Professor, Master’s supervisor, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China vip.ngxu8018@gzhtcm.edu. cn; yw8013@tom.com
  • About author:Rong Liu☆, Studying for doctorate, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China

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Abstract:

The present study established a model of focal cerebral ischemia through heat-coagulation induced occlusion of the middle cerebral artery. Following electroacupuncture at Baihui (GV20) and Dazhui (GV14), or intracerebroventricular infusion of AG490, a Janus kinase 2 phosphorylation inhibitor, the amount of necrotic or degenerated neurons in the ischemic cerebral cortex decreased, neuronal swelling was ameliorated, and expression of phosphorylated Janus kinase 2 and signal transducer and activator of transcription 3 decreased. Results confirmed that electroacupuncture promoted neuronal repair in the cerebral cortex by reducing expression of phosphorylated Janus kinase 2 and signal transducer and activator of transcription 3, as well as weakening the phosphorylated activation, thereby blocking abnormal activation of the Janus kinase 2- signal transducer and activator of transcription 3 signal transduction pathway.

Key words: cerebral ischemia, JAK2-STAT3, neurons, electroacupuncture, AG490