Abstract: The prevalence of Parkinson’s disease (PD) is rapidly increasing, and more than 12 million people are expected to suffer from PD by 2040. PD is a highly invalidating neurodegenerative condition that arises from the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. The main cause for such degeneration is the formation of cytoplasmic inclusions known as Lewy bodies, which include both misfolded α-synuclein (α-syn) protein and a multitude of fragmented membranes, organelles, and vesicles (Shahmoradian et al., 2019; Lashuel, 2020). No reliable biomarkers that can predict the onset of PD in its prodromal phase or could assess disease progression are currently available. α-Syn plays a pivotal role in the pathogenesis of PD and is present in peripheral tissues and biofluids; this led to the investigation of α-syn as a possible PD biomarker.