Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (9): 1971-1972.doi: 10.4103/1673-5374.335152

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Early life stress-induced neuroinflammation and neurological disorders: a novel perspective for research

Clarissa Catale, Valeria Carola*, Maria Teresa Viscomi*#br#   

  1. Division of Experimental Neuroscience, IRCCS Santa Lucia Foundation, Rome, Italy (Catale C, Carola V)
    Department of Dynamic and Clinical Psychology, and Health Studies, Sapienza University of Rome, Rome, Italy (Carola V)
    Department of Life Science and Public Health, Section of Histology and Embryology, Università Cattolica del S. Cuore, Rome, Italy (Viscomi MT)
  • Online:2022-09-15 Published:2022-03-05
  • Contact: Valeria Carola, PhD, valeria.carola@uniroma1.it; Maria Teresa Viscomi, PhD, mariateresa.viscomi@unicatt.it.
  • Supported by:
    This work was supported by the Italian Ministry of Health, Young Researcher Grant, No. GR-2009-1576820 (to VC) and by Linea D.1. 2019 Università Cattolica del S. Cuore (to MTV).

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Abstract: Childhood maltreatment (CM) has been consistently linked with numerous detrimental outcomes concerning physical and psychological health. However, few studies have explored vulnerability to neurological disorders after CM. Early life adversity, in the form of poverty, stress and abuse, has been associated with decline in cognitive function and dementia later in life (Short and Baram, 2019). Robust preclinical data suggest that early life stress (ELS) may increase the risk and worsen the course of neurological disorders such as Alzheimer’s (AD) and Parkinson’s (PD) diseases, and traumatic brain injury (TBI) (Lesuis et al., 2018; Short and Baram, 2019; He et al., 2020; Catale et al., 2021; Sanchez et al., 2021).