Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (11): 815-820.

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A non-opioid pathway for dynorphin-caused spinal cord injury in rats

Yu Chen, Liangbi Xiang, Jun Liu, Dapeng Zhou, Hailong Yu, Qi Wang, Wenfeng Han, Mingming Guo   

  1. Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province, China
  • Received:2011-12-02 Revised:2012-03-05 Online:2012-04-15 Published:2012-04-15
  • Contact: Liangbi Xiang, Master, Chief physician, Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province, China xiangliangbi1963@sina.com
  • About author:Yu Chen☆, M.D., Associate chief physician, Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province, China

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Abstract:

Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor.