Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (12): 2643-2648.doi: 10.4103/1673-5374.336135

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Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection

Ling-Ping Cen1, #, Tsz Kin Ng1, 2, 3, #, Wai Kit Chu3, Chi Pui Pang1, 3, *   

  1. 1Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong Province, China; 2Shantou University Medical College, Shantou, Guangdong Province, China; 3Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
  • Online:2022-12-15 Published:2022-05-05
  • Contact: Chi Pui Pang, DPhil, cppang@cuhk.edu.hk.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (81570849 to LPC), Joint Regional Basic Science and Applied Basic Science Research Fund of Guangdong Province (2019A1515110685 to TKN), Special Fund for Chinese Medicine Development of Guangdong Province (20202089 to TKN), the Natural Science Foundation of Guangdong Province (2020A1515010415 to LPC), an internal grant from Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Grant for Key Disciplinary Project of Clinical Medicine under the Guangdong High-level University Development Program, China, and The Chinese University of Hong Kong Direct Grant (2020.067 to WKC).

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Abstract: Both inflammation and anti-inflammation are involved in the protection of retinal cells. Antagonists of the hypothalamic growth hormone-releasing hormone receptor (GHRHR) have been shown to possess potent anti-inflammatory properties in experimental disease models of various organs, some with systemic complications. Such effects are also found in ocular inflammatory and neurologic injury studies. In experimental models of mice and rats, both growth hormone-releasing hormone receptor agonists and antagonists may alleviate death of ocular neural cells under certain experimental conditions. This review explores the properties of growth hormone-releasing hormone receptor agonists and antagonists that lead to its protection against inflammatory responses induced by extrinsic agents or neurologic injures in ocular animal models.

Key words: agonists, antagonists, growth hormone-releasing hormone receptor, macrophages, neuroprotection, ocular inflammation, optic nerve injury, retinal ganglion cells, uveitis