Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury

Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (11): 833-836.

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Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury

Feng Xiao¹, Liangzhi Xiong², Qingxiu Wang², Long Zhou¹, Qingshan Zhou³

1 Department of Anesthesiology, Affiliated Taihe Hospital of Yunyang Medical College, Shiyan 442000, Hubei Province, China
2 Department of Anesthesiology, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China
3 Department of Anesthesiology, People’s Hospital Affiliated to Wuhan University Medical College, Wuhan 430070, Hubei Province, China

Received:2011-11-05 Revised:2012-03-06 Online:2012-04-15 Published:2012-04-15
Contact: Qingxiu Wang, Department of Anesthesiology, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China
About author:Feng Xiao★, Master, Department of Anesthesiology, Affiliated Taihe Hospital of Yunyang Medical College, Shiyan 442000, Hubei Province, China

Abstract

Abstract:

A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ischemia/reperfusion significantly decreased infarct volume. Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus, but nuclear factor kappa B expression was unaltered. In addition, the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion. These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus.

Key words: ketamine, ischemia/reperfusion, c-Jun, nuclear factor kappa B, infarct volume

Feng Xiao, Liangzhi Xiong, Qingxiu Wang, Long Zhou, Qingshan Zhou. Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury[J]. Neural Regeneration Research, 2012, 7(11): 833-836.

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Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury

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