Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (1): 107-108.doi: 10.4103/1673-5374.343899

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A potential new tool to enhance translational success rate in stroke research by backcrossing techniques in transgenic mice

Takayuki Nakagomi*, Hideaki Nishie, Toshinori Sawano, Akiko Nakano-Doi   

  1. Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan (Nakagomi T, Nishie H, Nakano-Doi A)
    Department of Therapeutic Progress in Brain Diseases, Hyogo College of Medicine, Hyogo, Japan (Nakagomi T, Nakano-Doi A)
    Department of Biomedical Sciences, Ritsumeikan University, Shiga, Japan (Sawano T)
  • Online:2023-01-15 Published:2022-06-16
  • Contact: Takayuki Nakagomi, MD, PhD, nakagomi@hyo-med.ac.jp.
  • Supported by:
    This work was partially supported by Japan Society for the Promotion of Science (JSPS) KAKENHI (JP19K16934; to AN-D), Grant-in-Aid for researchers, Hyogo College of Medicine (2018; to AN-D), Hyogo College of Medicine Diversity Grant for Research Promotion under MEXT Funds for the Development of Human Resources in Science and Technology, Initiative for Realizing Diversity in the Research Environment (Characteristic-Compatible Type) (2020, 2021; to AN-D), and Grant-in-Aid for Graduate Students, Hyogo College of Medicine (2021; to HN).

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Abstract: Ischemic stroke is a leading disease of the central nervous system, frequently coupled to severe damage and dysfunction in patients. Animal models mimicking human stroke provide useful tools for studying the pathomechanisms (e.g., inflammation, neuroprotection, and neural regeneration), the treatment efficiency of various materials (e.g., bioactive molecules or drugs), and transplantation usefulness by various cell types [e.g., neural stem/progenitor cells (NSPCs), and mesenchymal or hematopoietic stem cells] under ischemic stroke.