Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (1): 139-140.doi: 10.4103/1673-5374.340408

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Regenerative capacity of Müller cells and their modulation as a tool to treat retinal degenerations

Federica M. Conedera, Volker Enzmann*   

  1. Advanced Microscopy Program, Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA (Conedera FM)
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA (Conedera FM)
    Department of Ophthalmology, University Hospital, University of Bern, Bern, Switzerland (Conedera FM, Enzmann V)
    Department of BioMedical Research, University of Bern, Bern, Switzerland (Enzmann V)
  • Online:2023-01-15 Published:2022-06-17
  • Contact: Volker Enzmann, PhD, Volker.Enzmann@insel.ch.

Abstract: Vision is one of our most precious senses, and its impairment has a high socio-economic impact. In the industrialized world, degenerative diseases of the retina lead to vision loss, particularly among the elderly. These degenerations include, for instance, retinitis pigmentosa, age-related macular degeneration, and diabetic retinopathy. Although treatments are evolving to manage late-stage symptoms of retinal degenerations, no effective therapies to recover vision loss exist. Retinal degeneration often involves loss or damage to specialized neural cells, such as photoreceptors, and their death stimulates the activation and proliferation of Müller cells (Salman et al., 2021).