Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (2): 114-118.

Previous Articles     Next Articles

Effects of minocycline on learning and memory of mice following ischemic-hypoxic cerebral injuries

Hongling Fan, Yuanyin Zheng, Lijuan Xu, Zhichao Zhong, Shining Cai, Shuling Zhang, Quanzhong Chang   

  1. Department of Physiology, Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong Province, China
  • Received:2011-09-15 Revised:2011-11-24 Online:2012-01-15 Published:2012-01-15
  • Contact: Quanzhong Chang, Doctor, Professor, Master’s supervisor, Department of Physiology, Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong Province, China cqzchang@tom.com
  • About author:Hongling Fan★, Studying for master’s degree, Department of Physiology, Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong Province, China

PDF

821

Abstract:

An ischemic-hypoxic animal model was established using right common carotid artery occlusions and inhalation of low concentrations of oxygen in mice. At 10 days after the ischemic-hypoxic injuries, saline-treated mice exhibited significantly prolonged escape latencies in water-maze tests and significantly shorter memory latencies and more mistakes in step-down tests. In contrast, mice treated with 5 mg/kg minocycline exhibited significant reversals of each of these effects compared with the saline-treated control mice. Moreover, we found that minocycline can relieve brain water content and morphological changes in mice following ischemic-hypoxic cerebral injuries. Accordingly, our findings indicate that minocycline provides some protections against the deleterious effects of these injuries in mice.

Key words: minocycline, ischemic-hypoxic cerebral injury, learning and memory, cognition