Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (17): 1606-1614.doi: 10.3969/j.issn.1673-5374.2013.17.009

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Neurotoxicity of cancer chemotherapy

Miyoung Yang1, 2, Changjong Moon1   

  1. 1 Department of Veterinary Anatomy, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, Republic of Korea
    2 Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
  • Received:2012-10-29 Revised:2013-01-15 Online:2013-06-15 Published:2013-06-15
  • Contact: Changjong Moon, D.V.M., M.S., Ph. D., Associate professor, Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, 300 Yongbong-Dong, Buk-Gu, Gwangju 500-757, South Korea, moonc@chonnam.ac.kr.
  • About author:Miyoung Yang☆, D.V.M., M.S., Ph.D., Post-doctoral fellow, MSU, USA.

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Abstract:

There is accumulating clinical evidence that chemotherapeutic agents induce neurological side effects, including memory deficits and mood disorders, in cancer patients who have undergone chemotherapeutic treatments. This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches. These investigations are helpful in determining how best to further explore the causal mechanisms of chemotherapy-induced neurological side effects and in providing direction for the future development of novel optimized chemotherapeutic agents.

Key words: neural regeneration, reviews, neurogenesis, behavioral dysfunction, chemotherapy, hippocampal dysfunction, memory deficit, mood disorder, neurodegeneration, neuron, neuroplasticity, neurotoxicity, grants-supported paper, neuroregeneration