Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (36): 2929-2936.

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Neurochemical metabolites in the medial prefrontal cortex in bipolar disorder

Osman Özdel1, Demet Kalayci2, Gülfizar Sözeri-Varma1, Yilmaz Kiro?lu3, Selim Tümkaya1,Tu?çe Toker-U?urlu1   

  1. 1 Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli 20100, Turkey
    2 Department of Psychiatry, Antalya Training and Research Hospital, Antalya 07050, Turkey
    3 Department of Radiology, Faculty of Medicine, Pamukkale University, Denizli 20100, Turkey
  • Received:2012-09-16 Revised:2012-11-04 Online:2012-12-25 Published:2012-12-25
  • Contact: Gülfizar S?zeri-Varma, M.D.,Assistant professor,Pamukkale Universitesi T?p Fakultesi, Psikiyatri AD, K?n?kl?, 20100, Denizli,Turkey gvarma@pau.edu.tr
  • About author:Osman ?zdel☆, M.D.,Associate professor,Department of Psychiatry,Faculty of Medicine,Pamukkale University,Denizli 20100, Turkey

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Abstract:

The aim of this study was to investigate proton magnetic resonance spectroscopy metabolite values in the medial prefrontal cortex of individuals with euthymic bipolar disorder. The subjects consisted of 15 patients with euthymic bipolar disorder type I and 15 healthy controls. We performed proton magnetic resonance spectroscopy of the bilateral medial prefrontal cortex and measured levels of N-acetyl aspartate, choline and creatine. Levels of these three metabolites in the medial prefrontal cortex were found to be lower in patients with bipolar disorder compared with healthy controls. A positive correlation was found between illness duration and choline levels in the right medial prefrontal cortex. Our study suggests that during the euthymic period, there are abnormalities in cellular energy and membrane phospholipid metabolism in the medial prefrontal cortex, and that this may impair neuronal activity and integrity.

Key words: bipolar disorder, proton magnetic resonance spectroscopy, medial prefrontal cortex, N-asetyl aspartate, choline, creatine, degradation, mood disorder, neurochemical metabolite, illness duration;neural regeneration