Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (5): 460-461.doi: 10.4103/1673-5374.130056

Previous Articles     Next Articles

Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury

Jessica M. Meves, Binhai Zheng   

  1. Neurosciences Graduate Program, Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, MC 0691, La Jolla, CA, USA
  • Received:2014-02-11 Online:2014-03-12 Published:2014-03-12
  • Contact: Binhai Zheng, Ph.D., Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, MC 0691, La Jolla, CA 92093-0691, USA, binhai@ucsd.edu.

PDF

1641

Abstract:

Recovery from injury to the CNS is limited, which is due in large part to the inability of axons to grow after injury. Unfortunately few experimental manipulations have been found that promote regeneration of damaged axons and functional recovery from injury. Nonetheless, targeting various axon growth inhibitors present in the CNS environment promotes compensatory growth of undamaged axons and functional recovery from experimental CNS injury, revealing an alternative approach to promoting functional recovery in patients.