Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (7): 719-726.doi: 10.4103/1673-5374.131576

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3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia

Wanhong Zhao, Chao Luo, Jue Wang, Jian Gong, Bin Li, Yingxia Gong, Jun Wang, Hanqin Wang   

  1. Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China
  • Received:2014-02-24 Online:2014-04-15 Published:2014-04-15
  • Contact: Hanqin Wang, M.D., Ph.D., Institute of Basic Medical Sciences, Faculty of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, Hubei Province, China, 117298088@qq.com.
  • Supported by:

    This study was financially supported by Innovation Team Project of Hubei Province 2011 Plans, No. 2011JH-2013CXTT06; Momentous Scientific Research Funds of Hubei Provincial Education Ministry, No. D20102101; and Cultivating Funds of Country’s Projects of Hubei University of Medicine, No. 2013GPY03.

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Abstract:

3-N-butylphthalide is an effective drug for acute ischemic stroke. However, its effects on chronic cerebral ischemia-induced neuronal injury remain poorly understood. Therefore, this study ligated bilateral carotid arteries in 15-month-old rats to simulate chronic cerebral ischemia in aged humans. Aged rats were then intragastrically administered 3-n-butylphthalide. 3-N-butylphthalide administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function. These findings suggest that 3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits.

Key words: nerve regeneration, depression, functional MRI, graph theory, complex networks, brain network, classification, feature selection, NSFC grant, neural regeneration

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