Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (9): 901-906.doi: 10.4103/1673-5374.133129

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Stem cells in neuroinjury and neurodegenerative disorders: challenges and future neurotherapeutic prospects

Tarek H. Mouhieddine 1, Firas H. Kobeissy 1, 2, Muhieddine Itani 3, Amaly Nokkari 4, Kevin K.W. Wang 2   

  1. 1 Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    2 Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, Gainesville, Division of Addiction Medicine, Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
    3 Faculty of Medicine, Saint George University of London, Nicosia, Cyprus
    4 Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon
  • Received:2014-04-15 Online:2014-05-20 Published:2014-05-20
  • Contact: Tarek H. Mouhieddine, M.D., Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon, tarek.mouhieddine@gmail.com.Kevin K.W. Wang, Ph.D., Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, Gainesville, Division of Addiction Medicine, Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA, kwang@ufl.edu.

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Abstract:

Neurodegenerative disorders cause irreversible damage to the brain and affect an increasing number of people worldwide. Although promising, the use of neuronal stem cells requires a better understanding of the process of neurogenesis. Various approaches have been used to control neurogenesis; however, all of these platforms presented major pitfalls. Therefore, an interesting future approach is to leverage the use of stem cell treatment and pharmacological agents such as ROCK inhibitors and growth factors to ameliorate neural deterioration.

Key words: neural stem cells, neurodegeneration, neuroinjury, TBI, rho-associated kinase (ROCK) inhibitor, BDNF, growth factors, stem cell therapy