Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (9): 919-923.doi: 10.4103/1673-5374.133133

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Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury

Fatemeh Anbari 1, Mohammad Ali Khalili 1, Ahmad Reza Bahrami 2, Arezoo Khoradmehr 1, Fatemeh Sadeghian 1, Farzaneh Fesahat  1, Ali Nabi 1   

  1. 1 Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
    2 Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
  • Received:2014-03-20 Online:2014-05-20 Published:2014-05-20
  • Contact: Mohammad Ali Khalili, Ph.D., Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, khalili59@hotmail.com.
  • Supported by:

    This study was supported by research center from Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

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Abstract:

To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells. 

Key words: nerve regeneration, bone marrow mesenchymal stem cells, traumatic brain injury,  , intravenous administration, cell differentiation, neurologic function, cerebral cortex, rats, neural  regeneration