Transferrin receptor and ferritin-H are developmentally regulated in oligodendrocyte lineage cells

doi:10.3969/j.issn.1673-5374.2013.01.001

Abstract

Abstract:

Iron is an essential trophic element that is required for cell viability and differentiation, especially in oligodendrocytes, which consume relatively high rates of energy to produce myelin. Multiple iron metabolism proteins are expressed in the brain including transferrin receptor and ferritin-H. However, it is still unknown whether they are developmentally regulated in oligodendrocyte lineage cells for myelination. Here, using an in vitro cultured differentiation model of oligodendrocytes, we found that both transferrin receptor and ferritin-H are significantly upregulated during oligodendrocyte maturation, implying the essential role of iron in the development of oligodendrocytes. Additional different doses of Fe³⁺ in the cultured medium did not affect oligodendrocyte precursor cell maturation or ferritin-H expression but decreased the expression of the transferrin receptor. These results indicate that upregulation of both transferrin receptor and ferritin-H contributes to maturation and myelination of oligodendrocyte precursor cells.

Key words: neural regeneration, neurogenesis, oligodendrocyte, iron, transferrin receptor, ferritin-H, development, myelinization, proliferation, induced differentiation, grants-supported paper, photographs-containing paper, neuroregeneration

Yunxia Li, Qiang Guan, Yuhui Chen, Hongjie Han, Wuchao Liu, Zhiyu Nie. Transferrin receptor and ferritin-H are developmentally regulated in oligodendrocyte lineage cells[J]. Neural Regeneration Research, 2013, 8(1): 6-12.

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