Plasticity of language pathways in patients with low-grade glioma

doi:10.3969/j.issn.1673-5374.2013.07.009

Abstract

Abstract:

Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively.

Key words: neural regeneration, neuroimaging, low-grade glioma, plasticity, language pathways, diffusion tensor imaging, fractional anisotropy, lateralization index, ventral language pathway, dorsal language pathway, glioma, grants-supported paper, photographs-containing paper, neuroregeneration

Gang Zheng, Xiaolei Chen, Bainan Xu, Jiashu Zhang, Xueming Lv, Jinjiang Li, Fangye Li, Shen Hu, Ting Zhang, Ye Li. Plasticity of language pathways in patients with low-grade glioma[J]. Neural Regeneration Research, 2013, 8(7): 647-654.

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