Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (14): 1276-1285.doi: 10.3969/j.issn.1673-5374.2013.14.004

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Changes of brain gray matter structure in Parkinson’s disease patients with dementia

Jianguo Xia1, Jinlin Miu2, Hongbin Ding1, Xiuping Wang1, Hua Chen1, Juan Wang3, Juan Wu4, Jingli Zhao4, Huanxin Huang5, Weizhong Tian1   

  1. 1 Department of Radiology, Taizhou People’s Hospital, Taizhou 225300, Jiangsu Province, China
    2 Department of Radiology, the Fourth People’s Hospital of Taizhou, Taizhou 225300, Jiangsu Province, China
    3 Department of Medical Image Engineering, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China
    4 Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
    5 Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
  • Received:2013-02-11 Revised:2013-04-20 Online:2013-05-15 Published:2013-05-15
  • Contact: Weizhong Tian, Master, Chief physician, Department of Radiology, Taizhou People’s Hospital, Taizhou 225300, Jiangsu Province, China, tz_twz@163.com.
  • About author:Jianguo Xia★, Master, Associate chief physician.

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Abstract:

Voxel-based morphometry is gaining considerable interest for studies examining Parkinson’s disease dementia patients. In this study, 12 patients with clinically defined Parkinson’s disease and dementia and 12 non-demented patients with Parkinson’s disease were examined using a T1WI three-dimensional fast spoiled gradient echo sequence. Gray matter data were analyzed using a voxel-based morphometry method and independent sample t-test based on Statistical Parametric Mapping 5 software. Differences in gray matter volume were represented with statistical parametric mapping. Compared with Parkinson’s disease patients without dementia, decreased gray matter volume in Parkinson’s disease dementia patients was observed in the bilateral superior temporal gyrus, bilateral posterior cingulate and left cingulate gyrus, right parahippocampal gyrus and hippocampus, right precuneus and right cuneus, left inferior frontal gyrus and left insular lobe. No increased gray matter volume was apparent. These data indicate that gray matter atrophy in the limbic system and cerebral neocortex is related to the presence of dementia.