Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (24): 2284-2289.doi: 10.3969/j.issn.1673-5374.2013.24.008

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Inner ear hair cell regeneration A look from the past to the future

Francisco Santaolalla1, 2, Carlos Salvador1, Agustín Martínez2, Jose María Sánchez2, Ana Sánchez del Rey2   

  1. 1 Department of Otorhinolaryngology, Basurto University Hospital, Bilbao, Bizkaia, Spain
    2 Department of Dermatology, Ophthalmology and Otorhinolaryngology, School of Medicine, University of the Basque Country (UPV/EHU), Bilbao, Bizkaia, Spain
  • Received:2013-03-15 Revised:2013-05-10 Online:2013-08-25 Published:2013-08-25
  • Contact: Francisco Santaolalla, M.D. Department of Otorhinolaryngology, Basurto University Hospital, Faculty of Medicine and Dentistry, University of the Basque Country (UPV/EHU), Gurtubay, s/n, 48013 Bilbao, Spain, francisco.santaolalla@ehu.es.

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Abstract:

Most recent studies on regeneration of inner ear hair cells focus on use of stem cells, gene therapy and neurotrophic factors. Cochlear gene therapy has been successfully used in the treatment of neu-rosensory hearing loss. This suggests that cochlear hair cell regeneration is possible. The objective of this paper is to review research and clinical application of inner near hair cell regeneration.

Key words: neural regeneration, reviews, hearing loss, hair cells, cochlea, genes, stem cells, viral vectors, re-generation, neuroregeneration