Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (25): 2343-2349.doi: 10.3969/j.issn.1673-5374.2013.25.005

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Danhong injection A modulator for Golgi structural stability after cerebral ischemia- reperfusion injury

Yan Wang, Zhiping Hu, Wei Lu   

  1. Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
  • Received:2013-05-13 Revised:2013-07-10 Online:2013-09-05 Published:2013-09-05
  • Contact: Zhiping Hu, Doctoral supervisor, Professor, Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China, huzhipingxy@gmail.com. Wei Lu, Master’s supervisor, Associate professor, Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China, luwei0338@sina.com.
  • About author:Yan Wang, Master.

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Abstract:

The cerebral ischemia-reperfusion model was established using the suture occlusion method, and rats were intraperitoneally given 8 mL/kg Danhong injection once a day prior to model establishment. Rat brain tissues were harvested at 6, 24, 48, 72 hours after reperfusion. Immunohistochemical staining showed that transforming growth factor-β1 expression increased, while Golgi matrix protein GM130 expression decreased after cerebral ischemia-reperfusion. Danhong injection was shown to significantly up-regulate the expression of transforming growth factor-β1 and GM130, and expres-sion levels peaked at 7 days after reperfusion. At 7 days after cerebral ischemia-reperfusion, Golgi morphology was damaged in untreated rats, while Golgi morphology breakage was not observed after intervention with Danhong injection. These experimental findings indicate that Danhong injec-tion can up-regulate the expression of transforming growth factor-β1 and GM130, and maintain Golgi stability, thus playing a neuroprotective role in rats after cerebral ischemia-reperfusion.