Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (27): 2501-2509.doi: 10.3969/j.issn.1673-5374.2013.27.001

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Efficacy of nanofibrous conduits in repair of long- segment sciatic nerve defects

Esmaeil Biazar1, Saeed Heidari Keshel2, 3, Majid Pouya4   

  1. 1 Department of Biomaterial Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran

    2 Student Research Committee, Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    3 Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

    4 Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
  • Received:2013-05-02 Revised:2013-07-16 Online:2013-09-25 Published:2013-09-25
  • Contact: Esmaeil Biazar, Ph.D., Department of Biomaterial Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran, kia_esm@yahoo.com.
  • Supported by:

    This work was supported by Tonekabon Branch, Islamic Azad University, Tonekabon, Iran, No. 73/442453.

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Abstract:

Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrate- co-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit and autologous sciatic nerve to bridge 30-mm-long rat sciatic nerve gaps. Within 4 months after surgery, rat sciatic nerve functional re-covery was evaluated per month by behavioral analyses, including toe out angle, toe spread anal-ysis, walking track analysis, extensor postural thrust, swimming test, open-field analysis and noci-ceptive function. Results showed that rat sciatic nerve functional recovery was similar after nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit and autologous nerve grafting. These findings suggest that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit is suitable in use for repair of long-segment sciatic nerve defects.

Key words: neural regeneration, peripheral nerve injury, sciatic nerve, nerve conduit, poly(3-hydroxybutyrate- co-3-hydroxyvalerate, behaviors, motor function, nociceptive function, grants-supported paper, neuroregeneration