Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (36): 3410-3415.doi: 10.3969/j.issn.1673-5374.2013.36.006

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Immediate versus delayed primary nerve repair in the rabbit sciatic nerve

Ahmet Piskin1, Berrin Zühal Altunkaynak2, Atilla Çıtlak3, Hicabi Sezgin1, Ozgür Yazıcı1, Süleyman Kaplan2   

  1. 1 Department of Orthopedics and Traumatology, School of Medicine, Ondokuz May?s University, Samsun, Turkey
    2 Department of Histology and Embryology, School of Medicine, Ondokuz May?s University, Samsun, Turkey
    3 Department of Orthopedics and Traumatology, School of Medicine, Giresun University, Giresun, Turkey
  • Received:2013-10-18 Revised:2013-11-23 Online:2013-12-25 Published:2013-12-25
  • Contact: Atilla ??tlak, M.D., Assistant professor, Department of Orthopedics and Traumatology, School of Medicine, Giresun University, Giresun, Turkey, atillacitlak@yahoo.com.
  • About author:Ahmet Piskin, Associate professor.

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Abstract:

It is well known that peripheral nerve injury should be treated immediately in the clinic, but in some instances, repair can be delayed. This study investigated the effects of immediate versus delayed (3 days after injury) neurorrhaphy on repair of transected sciatic nerve in New Zealand rabbits using stereological, histomorphological and biomechanical methods. At 8 weeks after immediate and de-layed neurorrhaphy, axon number and area in the sciatic nerve, myelin sheath and epineurium thickness, Schwann cell morphology, and the mechanical property of nerve fibers did not differ ob-viously. These results indicate that delayed neurorrhaphy do not produce any deleterious effect on sciatic nerve repair.

Key words: neural regeneration, delayed peripheral nerve repair, sciatic nerve, peripheral nerve injury, stereology, microscopy, biomechanics, neuroregeneration