Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (36): 3434-3440.doi: 10.3969/j.issn.1673-5374.2013.36.009

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Angiogenin gene polymorphism A risk factor for diabetic peripheral neuropathy in the northern Chinese Han population?

Hongli Wang, Dongsheng Fan, Yingshuang Zhang   

  1. Department of Neurology, Peking University Third Hospital, Beijing 100191, China
  • Received:2013-08-11 Revised:2013-11-12 Online:2013-12-25 Published:2013-12-25
  • Contact: Dongsheng Fan, Ph.D., Doctoral supervisor, Chief physician, Department of Neurology, Peking University Third Hospital, Beijing 100191, China, dsfan@sina.com.
  • About author:Hongli Wang, Ph.D., Attending physician.
  • Supported by:

    This study was financially sponsored by the Natural Science Foundation of Beijing, No. 7102161.

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Abstract:

Angiogenin is associated with the pathogenesis of diabetic peripheral neuropathy. Here, we se-quenced the coding region of the angiogenin gene in genomic DNA from 207 patients with type 2 diabetes mellitus (129 diabetic peripheral neuropathy patients and 78 diabetic non-neuropathy pa-tients) and 268 healthy controls. All subjects were from the Han population of northern China. No mutations were found. We then compared the genotype and allele frequencies of the angiogenin synonymous single nucleotide polymorphism rs11701 between the diabetic peripheral neuropathy patients and controls, and between the diabetic neuropathy and non-neuropathy patients, using a case-control design. We detected no statistically significant genetic associations. Angiogenin may not be associated with genetic susceptibility to diabetic peripheral neuropathy in the Han population of northern China.

Key words: neural regeneration, angiogenin, single nucleotide polymorphism, type 2 diabetes mellitus, diabetic peripheral neuropathy, angiogenesis, diabetic microvascular complications, genetic susceptibility, risk factor, peripheral nerve injury, grants-supported paper, neuroregeneration