Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (3): 276-279.doi: 10.4103/1673-5374.128221

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Vascular changes caused by deep brain stimulation using double-dose gadolinium-enhanced brain MRI

Byeong Sam Choi1, Yong Hwan Kim2, Sang Ryong Jeon3   

  1. 1 Department of Neurological Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
    2 Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN, USA
    3 Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • Received:2013-11-14 Online:2014-02-15 Published:2014-02-15
  • Contact: Sang Ryong Jeon, M.D., Ph.D., Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43gil, Songpa-gu, Seoul, Korea, srjeon@amc.seoul.kr.
  • Supported by:

    This work was supported by a KRCF National Agenda Project.

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Abstract:

We retrospectively analyzed the clinical data of 32 patients with medically intractable idiopathic Parkinson’s disease who had undergone staged bilateral deep brain stimulation of the subthalamic nuclei from January 2007 to May 2011. The vascularture of the patients who received two deep brain stimulations was detected using double-dose gadolinium-enhanced brain MRI. The dimensions of straight sinus, superior sagittal sinus, ipsilateral internal cerebral vein in the thalamic branch and ipsilateral anterior caudate vein were reduced. These findings demonstrate that bilateral deep brain stimulation of the subthalamic nuclei affects cerebral venous blood flow.

Key words: nerve regeneration, gadolinium-enhanced brain MRI, deep brain stimulation, subthalamic nuclei, vascularture, straight sinus, superior sagittal sinus, internal cerebral vein in the thalamic branch, anterior caudate vein, KRCF National Agenda Project, neural regeneration