Neural Regeneration Research

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Role of P2X7 receptors in neuronal death in the retina

Tetsuya Sugiyama 1, 2   

  1. 1 Nakano Eye Clinic of Kyoto Medical Co-operative, Kyoto 604-8404, Japan
    2 Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan
  • Received:2014-02-25 Online:2014-03-22 Published:2014-03-22
  • Contact: Tetsuya Sugiyama, M.D., Ph.D., Nakano Eye Clinic of Kyoto Medical Co-operative, 2 Jurakukaitou-Cho, Nakagyo-Ku, Kyoto, 604-8404, Japan, tsugiyama@poh.osaka-med.ac.jp.

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Abstract:

The P2X7 receptor is a member of the family of purinoceptors. In addition to its physiological roles, its stimulation has been reported to be involved in neuronal death in the retina. Its stimulation may also exert a deleterious effect on retinal ganglion cells in glaucomatous eyes, being associated with the up-regulation of inflammatory cytokine expression. P2X7 receptor is a potential therapeutic target of pharmacological strategies designed to prevent neuronal death in ocular diseases including glaucoma.