Neural Regeneration Research

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The metabolic brain network in patients with Parkinson’s disease based on 18F-FDG PET imaging: evaluation of neuronal injury and regeneration

Jingjie Ge, Ping Wu, Chuantao Zuo   

  1. PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
  • Received:2014-03-19 Online:2014-04-15 Published:2014-04-15
  • Contact: Chuantao Zuo, PET Center, Huashan Hospital, Fudan University, No. 518 East Wuzhong Road, Xuhui District, Shanghai, China, zuoct_cn2000@126.com.
  • Supported by:

    This work was supported by grants from the China-US Biomedical Collaborative Research Program (No. 81361120393) and the National Foundation of Natural Science of China (No.81171189).

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Abstract:

Over the past two decades, the development of functional imaging methods has greatly promoted our understanding on the changes of neurons following neurodegenerative disorders. Prof. Chuantao Zuo from Fudan University in China proposed that the application of a spatial covariance analysis on 18F-FDG PET imaging has led to the identification of a distinctive disease-related metabolic pattern. This pattern has proven to be useful in clinical diagnosis, disease progression monitoring as well as assessment of the neuronal changes before and after clinical treatment. It may potentially serve as an objective biomarker on disease progression monitoring , assessment , histological and functional evaluation of for related diseases.