Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (8): 798-805.doi: 10.4103/1673-5374.131596

Previous Articles     Next Articles

Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer’s disease mice

Yufang Yan 1, Tuo Ma 1, Kai Gong 1, Qiang Ao 2, Xiufang Zhang 1, Yandao Gong 1   

  1. 1 State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing, China
    2 Institute of Neurological Disorders, Yuquan Hospital, Tsinghua University, Beijing, China
  • Received:2014-03-24 Online:2014-04-25 Published:2014-04-25
  • Contact: Yandao Gong, State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China, gongyd@tsinghua.edu.cn.
  • Supported by:

    This work was supported by the National High-Tech Research and Development Program of China (863 Program), No. 2012AA020905; Tsinghua-Yue-Yuen Medical Sciences Fund, No. 20240000514.

PDF

1461

Abstract:

In the present study, we transplanted adipose-derived mesenchymal stem cells into the hippocampi of APP/PS1 transgenic Alzheimer’s disease model mice. Immunofluorescence staining revealed that the number of newly generated (BrdU+) cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in Alzheimer’s disease mice after adipose-derived mesenchymal stem cell transplantation, and there was also a significant increase in the number of BrdU+/DCX+ neuroblasts in these animals. Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well. Furthermore, adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice. Based on these findings, we propose that adipose-derived mesenchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer’s disease mice, thereby facilitating functional recovery.

Key words: nerve regeneration, stem cells, Alzheimer’s disease, adipose-derived mesenchymal stem cells, cell transplantation, cognitive impairment, oxidative stress, neurogenesis, 863 Program, neural regeneration