Abstract:

Ginkgo Biloba (G. biloba) is a widely studied herb for the treatment of neurological disorders, its use as a symptomatic treatment for dementia has been established in clinical trials. However, its use for the treatment of ischemic stroke in the clinic is still equivocal. EGb 761-treated mice not only showed an increase in the number of NSCs post-stroke, but the majority of them were found in the proximity of the injury site or penumbra area. EGb 761 also enhanced the expression of Wnt, the ligand that is responsible for triggering the canonical Wnt pathway or the Wnt/β-catenin pathway, which constitutes one of the primary signaling mechanisms overseeing endogenous neurogenesis. Thus, EGb 761 can offer a diverse trove of potential drug leads that could someday change the way we think of nerve regeneration and the use of complementary and alternative medicine.