Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (16): 1557-1566.doi: 10.4103/1673-5374.139483

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Neuroprotective effects of berry fruits on neurodegenerative diseases

Selvaraju Subash 1, 2, Musthafa Mohamed Essa 1, 2, Samir Al-Adawi 2, 3, Mushtaq A. Memon 4, Thamilarasan Manivasagam 5, Mohammed Akbar 6   

  1. 1 Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman
    2 Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Sultanate of Oman
    3 College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman
    4 College of Veterinary Medicine, Washington State University, Pullman, WA, USA
    5 Department of Biochemistry and Biotechnology, Annamalai University, Tamilnadu, India
    6 Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
  • Received:2014-07-02 Online:2014-08-22 Published:2014-08-22
  • Contact: Musthafa Mohamed Essa, Ph.D., Department of Food Science and Nutrition, P.O. 34, College of Agricultural and Marine Sciences, Sultan Qaboos University, Al-Khoud, Muscat, P.C. 123, Sultanate of Oman, drmdessa@squ.edu.om.
  • Supported by:

    This study was supported by a grant from the Research Councial of Sultanate of Oman, No. RC/AGR/FOOD/11/01.

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Abstract:

Recent clinical research has demonstrated that berry fruits can prevent age-related neurodegenerative diseases and improve motor and cognitive functions. The berry fruits are also capable of modulating signaling pathways involved in inflammation, cell survival, neurotransmission and enhancing neuroplasticity. The neuroprotective effects of berry fruits on neurodegenerative diseases are related to phytochemicals such as anthocyanin, caffeic acid, catechin, quercetin, kaempferol and tannin. In this review, we made an attempt to clearly describe the beneficial effects of various types of berries as promising neuroprotective agents.