Neural Regeneration Research ›› 2015, Vol. 10 ›› Issue (10): 1537-1539.doi: 10.4103/1673-5374.165215

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Ischemic long-term-potentiation (iLTP): perspectives to set the threshold of neural plasticity toward therapy

Maximilian Lenz1, 2, Andreas Vlachos2, Nicola Maggio1, 3, *   

  1. 1 Department of Neurology, The J. Sagol Neuroscience Center, The Chaim Sheba Medical Center, Tel HaShomer, Israel
    2 Institute of Clinical Neuroanatomy, Neuroscience Center Frankfurt, Goethe-University Frankfurt, Frankfurt, Germany
    3 Talpiot Medical Leadership Program, The Chaim Sheba Medical Center, Tel HaShomer, Israel
  • Received:2015-07-30 Online:2015-10-28 Published:2015-10-28
  • Contact: Nicola Maggio, M.D., Ph.D.,nicola.maggio@sheba.health.gov.il.
  • Supported by:

    This work was supported by German Israeli Foundation (G-1317-418.13/2015 to AV and NM)

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Abstract:

The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that synaptic plasticity induced by a pathological stimulus, i.e., ischemic long-term-potentiation (iLTP) of excitatory synapses, could play an important role for post-stroke recovery by influencing the post-lesional reorganization of surviving neuronal networks.

Key words: ischemic LTP (iLTP, stroke, neural repair, synaptic plasticity, neural homeostasis